Monoclonal Antibodies: From Screening To Production

The production of monoclonal antibodies is well understood, scalable and standardized to the extent that it makes a good generic example of a modern bioprocess.

The main steps in monoclonal antibody manufacturing include:

• Creation and selection of the hybridoma clone for a master seed
• Preparing seed train in either T-flasks, shake flasks or roller bottles
• Moving to bench-scale bioreactors (option bags) to increase seed yield
• Production up to 20,000 L
• Downstream processing and storage

Read through overviews of each of these steps in detail to understand why monoclonal antibodies are a prime example of a modern bioprocess involving skills in multiple scientific disciplines.