Modulating The Effectiveness Of mRNA Therapies Using Modified Ribonucleotides

In vitro transcribed mRNA has become an effective and scalable therapeutic modality for a wide range of disease indications after the successful development of two COVID-19 vaccines. The product only works effectively if the injected mRNA does not generate immunotoxicity, which is where modified ribonucleotides are useful in boosting the safety of these vaccines and therapeutics. Learn about the immunogenicity of mRNA and reducing it, the production of modified mRNA via in vitro transcription, and choosing fit-for-purpose modified ribonucleotides.