Mobius® iFlex Bioreactors Scalability And Performance Guide

Intensified bioprocessing arises from an increased need for high-quality drug supply while lowering facility footprints and production costs. Specifically, upstream processes are adopting intensified fed-batch and perfusion within single-use bioreactors to realize higher flexibility and increased product yields. The Mobius® iFlex bioreactor platform offers single-use, stirred tank systems designed to support both traditional fed-batch and perfusion-intensified cell culture applications. Performance attributes of the impeller, spargers, Ultimus® film, and sensors were characterized to determine the effective design space and operating range for accurate process monitoring and control. Scalability data developed in representative systems with volumes ranging from 50 L to 2000 L are also presented as a guide for process development and cross-scale performance expectations.
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