Mirus Bio Bio-Expo Live November 2026: Upstream Bioprocessing

Maximizing adeno-associated virus yield at the harvest stage is essential for reducing the overall production costs of gene therapies and accelerating clinical development. Upstream transfection efficiency directly dictates downstream recovery limits, making the optimization of plasmid delivery systems a critical engineering priority. Modern production platforms leverage advanced polymer-lipid formulations and specialized cellular enhancers to overcome intracellular membrane barriers while significantly lowering required DNA and reagent quantities. Furthermore, incorporating novel complex stabilizers enables extended holding times and manageable fluid volumes during large-scale manufacturing runs in stirred-tank bioreactors. Explore how these innovative transfection solutions streamline viral vector production and improve capsid quality across diverse serotypes and scales.