Mapping The Cell Signaling Web Can Lead To New Therapies

Signaling pathways are how important internal cellular communication occurs. They control the regulation of critical cellular processes, such as autophagy, apoptosis, transcription, cell cycle progression, and proliferation. The understanding of signaling networks has significant potential to advance therapies in cancer and regenerative medicine. However, gaining an accurate quantitative understanding of signaling networks as a whole is crucial and remains a daunting challenge. The limitations of traditional methods like Western blot in this regard are significant because they lack throughput, multiplexing efficiency, sensitivity, and quantitation to gain a holistic view of cell signaling.

This paper highlights scientific articles that demonstrate how Simple Western and Single-Cell Western provide a holistic overview of signaling pathways in many different cell types, organisms, and environments, from the study of cancer to the impact of spaceflight.