Webcast: mAb Purification Process Development Using Mixed-Mode Resins — The DOE Approach

This presentation features a case study of two-step mAb purification workflow and compares two multimodal resin alternatives used for the polishing step post–protein A capture. Data demonstrating the behavior of multiple mAbs with these two different mixed-mode resins and the design of experiments (DOE) are shown. The importance of scale, prior knowledge, and the development stage will also be discussed. Both mixed-mode resin studies and their different DOE approaches to development are shown to achieve high-purity products.