Lyostat 4 Freeze Drying Microscope

Freeze Drying Microscopy is a popular and well-established lyophilisation analysis technique. As well as the traditional critical temperatures, such as the eutectic melting temperature (Teu) and collapse temperature (Tc), BTL’s latest generation FDM, Lyostat 4, also enables the identification of crystallisation phenomena, skin/crust formation, and the effects of annealing on ice crystal growth and solute structure. Knowledge of the critical temperatures is essential to conduct cycle development on a rational, quantitative scientific basis as well as saving precious resources in terms of time and monies needed.

Lyostat 4 is supplied fully validated as a complete working system against a series of standard solutions. Full installation and training is offered as standard. Uniquely, as well as instructing correct use of the equipment, our training provides practical tuition on interpretation of results from scientists with in-depth knowledge of freeze drying. Installation and operation qualification (IQ/OQ) packages are also available, and can be customised to bespoke specifications if required. The Lyostat 4 is PC controlled to provide sophisticated image and data capture and analysis functions, which also allows the user to make a video of their sample under analysis. The software is also available in a 21CFR11 compliant version.