The ÄKTA oligosynt™ oligonucleotide synthesizer is a compact, fully automated oligonucleotide synthesizer built for research and process development laboratories (Fig 1). The system supports a robust and easily scalable oligonucleotide synthesis process and transfer to larger oligonucleotide synthesizers with high yield and quality.
The ÄKTA oligosynt™ system’s flow-through technology, high pump accuracy, wide scale and the low hold-up volume make it suitable for different scales and types of oligonucleotides. Process development and optimization are supported by flexible and easy method creation and transfer that support scale up, while the system’s advanced data processing capabilities and analytical tools allow efficient monitoring and control of the synthesis. An interactive process picture (Fig 4), placement of all modules on system front, and transparent method overview make the system easy to use.
- The broad synthesis scale and optimized hold-up volume combined with a small system footprint enable a broad and flexible use for research and development requirements.
- Flexible and easy method editing, and the interactive user interface offer ease of use and support scale-up requirements.
- Robust process control is supported by sensors measuring pressure, air, temperature, UV, and conductivity. Input from external modules is also possible.