Key Requirements For Scale-Up Of Shear Sensitive Pluripotent Stem Cell And Other Cell Therapy Products Using Vertical-Wheel Bioreactors

The promise of cell therapies hinges on our ability to produce consistent, high-quality cell yields at scale. However, shear-sensitive cell types like pluripotent stem cells (PSCs) present significant challenges during scale-up. Traditional bioreactor systems often introduce damaging shear forces, hindering cell viability and process reproducibility.

This poster addresses these critical challenges, presenting key requirements for efficient and linear scale-up of PSCs and other cell therapy products using the innovative vertical-wheel bioreactor family. Learn about the robust 2D seed train process designed for reproducibility and scalability and linear scale-up of PSC expansion from small 0.1L volumes to large 80L scales, showcasing the system's capacity for industrial-scale production. Crucial solutions for large-scale medium exchange and efficient gas transfer are also presented. The poster also details scalable, low-shear methods for cell harvest, washing, and concentration, ensuring maximal product recovery.

Eager to learn how these advancements can revolutionize your cell therapy manufacturing? Click below to access the full poster.