IVGE Process And Optimization

Achieve greater control over therapeutic protein glycosylation with in vitro glycoengineering (IVGE). Traditional cell culture methods often result in a mix of glycan patterns, a critical quality attribute that needs to be controlled. IVGE from Roche Custom Biotech offers a solution by separating glycosylation from cell culture fermentation, allowing for independent optimization of yield and glycan profiles. This enzymatic, cell-free process modifies N-linked glycans after protein harvest, enabling the production of more homogeneous glycoproteins.

Discover how to optimize conditions like enzyme ratios and reaction times for consistent results. Watch the video to learn more about implementing the IVGE process.