IsoClear A™ & IsoClear B™ Chromatography Adsorbents

Isoagglutinins are antibodies (IgM and IgG isotypes) which recognise and bind to type A or B blood group antigens. The presence of isoagglutinin antibodies in plasma derived products (particularly plasma for transfusion and IVIG) can give rise to serious side effects, such as haemolysis, depending upon the type of isoagglutinin present (A or B) and the blood type of the recipient.

Astrea Bioseparations have developed two affinity chromatography adsorbents (IsoClear A™ & IsoClear B™) comprising of immobilized trisaccharide blood group antigens (A & B). These antigens are chemically synthesized and covalently attached to a biocompatible polymethacrylate support matrix. IsoClear A™ and IsoClear B™ adsorbents are highly selective for the removal of isoagglutinin antibodies, enabling cost effective and efficient reduction of isoagglutinin titre for plasma and plasma derived products.