Introduction To Antibody Libraries For Display-Based Antibody Discovery

By Raphael Levy, Ph.D.

Protein engineering has been revolutionized by the development of in vitro display platforms, which enable the presentation of individual proteins or vast libraries of variants on the surface of living systems such as mammalian cells, yeast, bacteria, or even bacteriophage capsids. These platforms allow for precise selection and optimization of peptides, antibodies, or other protein-based therapeutics based on their binding characteristics, stability, and functionality — significantly accelerating the discovery and refinement process. Among the most widely used techniques are phage display and yeast surface display, each offering distinct advantages for different applications in antibody discovery and engineering.

At Curia, we combine deep scientific expertise with these powerful technologies to support the efficient identification, screening, and optimization of antibody candidates. Explore how our capabilities in phage and yeast surface display can drive your next protein engineering or therapeutic antibody development project forward.