Newsletter | November 17, 2025

11.17.25 -- How Sethera Harnesses A Promiscuous Enzyme To Make Recombinant Peptides

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FOCUS ON UPSTREAM MANUFACTURING

How Sethera Harnesses A Promiscuous Enzyme To Make Recombinant Peptides

A class of enzymes previously believed to be specific and intolerant of change might actually have broad applicability.

The Impact Of Manipulation Of Fermentation Broth On Fungal Biomass

Explore how adding Iron and B12 to fungal fermentation media increases nutritional content and impacts the biomass's texture and flavor profile, optimizing production for novel food applications.

A Novel Approach To Improving AAV Titers

Simple cell culture media supplementation post-infection can significantly increase AAV titers and the proportion of full capsids, streamlining the path to high-volume viral vector manufacturing.

Stable Bulk Cultures: A Fast Path To Antibody Manufacturing

The potential advantages that stable bulk cultures can offer a drug development paradigm are poised to accelerate and bolster biopharmaceutical clinical manufacturing.

How To Maximize Cell Line Productivity And Efficiency

Explore some of the key considerations in cell line development, how advances in technology are improving the efficiency and productivity of cell lines, and the future of cell line development.

From R&D Tool To GMP Solution: Is Glycoengineering Ready For Your Plant?

In this assessment of the in vitro glycoengineering technology we determine if it is suitable for the development, manufacturing, and analysis of therapeutic proteins.

PSC Perfusion Guidance Using Vertical-Wheel Bioreactors

Unlock the potential of perfusion for pluripotent stem cell cultures. Explore key insights into achieving improved consistency and quality in your medium exchange protocols, leading to better outcomes.

Cell Harvesting: A Strategic Lever In Allogeneic Therapy Production

Current cell harvest techniques in allogeneic manufacturing face limitations, including scalability issues and cell damage. Learn why a shift in approach is vital for high-quality, efficient production at scale.

Study Of Small Bioreactor Expansion Kinetics During Expansion Protocol

Mesenchymal stem cells have been used to show equivalent expansion kinetics during a 7-day expansion protocol on both the small and standard bioreactors revealing efficiency differences.

A Transient Cell Line To Produce rAAV With Low-Level hcDNA Encapsidation

Discover the ability of a novel HEK293 suspension cell line for efficient and scalable rAAV production across various serotypes with low encapsidated host cell DNA levels.

UPSTREAM MANUFACTURING SOLUTIONS

Pioneers And Visionaries: Cell Line Development And AAV Gene Therapy - Cytiva

Upstream Bioprocess Equipment For Commercial Manufacturing - Eppendorf SE

Zero Time to Master: PharmaLok ZerO - Nordson MEDICAL

Technology To Help Accelerate Translation From Concept To Clinic - MaxCyte, Inc.

A Scaled-Down Solution For Simple, Robust Upstream Intensification - Repligen

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