Article | October 7, 2019

How Can Extrusion Benefit Your Pharmaceutical Oral Drug Product?

Source: AbbVie

By Bei Chen

Hot Melt Extrusion Pharmaceutical Formulation

Extrusion processing is intended to continuously manufacture homogeneous and structured products. Due to its immense adaptability, extrusion has been widely utilized in diverse fields.  It is being adopted more recently by the pharmaceutical industry at an unprecedented pace to address various drug product formulation and manufacturing needs. The twin screw extrusion process can be used to not only manufacture novel drug delivery systems but also replace batch granulation processes. During extrusion, powder blend(s) or a granular mix is compacted, forced through an orifice under controlled conditions and finally converted into a product with defined shape and density. Compared to a traditional batch process, this exciting yet complex technology offers many advantages including but not limited to excellent product uniformity and higher manufacturing efficiency.

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