High-Yield Cell Therapy Bioproduction With The Corning® CellCube® System

Clinical programs built on dental pulp stem cells need billions to trillions of cells per batch, and the usual routes to that scale each carry costs. Static multilayer systems demand space, labor, and media. Microcarriers complicate harvest and downstream processing. This case study follows S-Quatre, a Japanese regenerative medicine company developing SHED-based therapies, as it searched for a closed, planar platform that could scale without compromising cell quality. Masashi Yamada, Director of Manufacturing Development at S-Quatre Corporation, describes the requirements the team set, how tech transfer and process optimization unfolded, and the yield, media, and potency results they measured at two module sizes.

Explore the S-Quatre experience to see what the numbers showed.