Hamilton Bonaduz AG recently published a whitepaper regarding Process Analytical Technology (PAT) in the biopharma industry. The 20-page document introduces the process parameters and key performance indicators as well as process analysis devices for bioreactors. “We illustrate concisely, yet with sufficient detail, what one needs to know regarding PAT and bioreactors”, states Giovanni Campolongo, Market Segment Manager - Process Analytics at Hamilton Bonaduz AG. Important PAT concepts such as Critical Quality Attributes (CQA), Critical Process Parameters (CPP), and Key Performance Indicators (KPI) are explained comprehensively with meaningful examples in order to establish a strong foundational understanding of the PAT initiative. The whitepaper demonstrates the possibility of higher product yield and quality through proper PAT implementation. Toward this end, the whitepaper provides a comprehensive overview of different culture and fermentation process types, as well as of different analytical process monitoring methods. “We introduce, not just the theory, but also examples of different applications so that the reader understands how PAT works in practice”, discloses Giovanni Campolongo. The English-language whitepaper is available on http://processanalytics.hamiltoncompany.com/pat-whitepaper free of charge.
Hamilton Company is a global enterprise with affiliates in Reno, Nevada; Franklin, Massachusetts (both USA); and Bonaduz, Switzerland, and sales offices throughout the world.
Hamilton Company is an industry leader in the design and manufacture of liquid handling, process analytics, robotics, and automated storage solutions. For more than 60 years, Hamilton Company has been satisfying customer needs by combining quality materials with skilled workmanship to ensure the highest level of performance. Hamilton Company’s lifelong commitment to precision and quality has earned us global ISO 9001 Certification.
In 2014, Hamilton celebrated the 25th birthday of the sensor business. It started with pH sensors and has been growing ever since. Today the portfolio covers the parameters pH, ORP, conductivity, and dissolved oxygen (DO) as well as total and viable cell density. All these parameters are crucial in the biopharma, chempharma and brewery markets. The Hamilton offering encompasses the whole measuring loop: sensors, cables, housings, transmitters, buffers, standards, and other accessories. Top innovations include Arc sensors with integrated micro-transmitters making external transmitters obsolete, VisiPro DO - the only optical dissolved oxygen sensor available with ATEX / IECEx approval - and EasyFerm Bio with the fully biocompatible reference electrolyte Foodlyte.
SOURCE: Hamilton Company