Newsletter | January 15, 2025

01.15.25 -- Go From Batch To Continuous RNA Purification With mAb Equipment And QBD

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Let Us Handle Your Buffer Preparation

Thermo Fisher Scientific is here to support you with the buffer preparation in your manufacturing workflow. Leaving the non-core activities to us enables you to focus on the patient therapy development. Our capabilities cover off-the-shelf products like WFI, NaOH, NaCl, or EtOH, a library of the most frequently used buffers that are made-to-order, as well as fully customized buffers.

FOCUS ON DOWNSTREAM MANUFACTURING

From Batch To Continuous RNA Purification With mAb Equipment And QBD

University of Sheffield researchers developed a novel method to purify polyadenylated mRNA continuously, which stands to improve productivity and efficiency.

Maximizing Yield And Minimizing Risk In Aseptic Filling

Explore the process of how a new fill line was planned for and implemented, while also considering how best to mitigate contamination risks.

Constraints And Solutions For Biopharmaceutical Manufacturing

Dissect the reasons for capacity bottlenecks stemming from process development scope, downstream chromatography, and equipment constraints, and delve into the potential solutions associated with each.

Downstream Processing Solutions For Lentiviral Purification

Third-generation lentiviral vectors enable efficient gene delivery, but purification challenges limit in vivo applications. Monolithic columns and advanced assays show promise for downstream processes.

Developing A Large-Scale Tangential Flow Filtration Process

Discover a process that can be modified to fit your downstream process and serves as a complete solution for concentration and diafiltration.

Switching From Vials To PFS And Intravenous To Subcutaneous Formulations

Learn about formulation development challenges for prefilled syringes as well as considerations for reducing the time it takes to launch safer, more convenient, and cost-effective products for the patient.

TFF Cassettes With 100 kDa Membranes For RNA And LNP Applications

This study showcases the performance of regenerated cellulose flat sheet membranes with a 100 kDa molecular weight cutoff for UF/DF of RNA molecules by TFF.

CHT Chromatography Media: 5 Essential Facts

CHT provides exceptional removal of impurities when other chromatography resins fall short to provide the same level of purity. Explore the essential facts and benefits of this chromatography technology.

Adopting Novel Technologies To Improve Monoclonal Antibody Processes

What are the four new-edge production technologies that better remove impurities, reduce aggregation and improve stability

DOWNSTREAM MANUFACTURING SOLUTIONS

Pharma+ Tubing Retainers - Nordson MEDICAL

Streamline Mass Photometry Measurement Workflows With MassFerence P2 - Refeyn

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Following its popular inaugural 2024 Bio-Expo Live, Bioprocess Online brings you the next opportunity to advance your drug development agenda. Over just a small portion of your week and from the comfort of your computer, discover the latest solutions in upstream and downstream bioprocessing as well as bioprocess quality, data, and analytics. 15-minute presentations from leading suppliers will give you just the right insight to make your next best move in drug development. Register here.

FOCUS ON FILL-FINISH

The Successful Implementation Of A New Aseptic Filling Line

Discover how a Quality by Design approach can streamline the development of new sterile product filling lines, featuring a real-life example illustrating its effectiveness.

Fluid Connection Technologies For Sterile Fill and Finish Process Design

Single-use technology and innovative fluid connections play a significant role in creating an effective, sterile fill and finish operation that maintains the integrity of your biologic products.

FILL-FINISH SOLUTIONS

Easy Early Drug Development With Small Quantities - West Pharmaceutical Services, Inc.

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