Genetic Stability Testing Using NGS And MAM: Optimizing CHO Cell Line Development

By Valentina Armiento, Scientific Communications

This content is brought to you by Genedata, a Danaher Operating Company.

As biologics continue to expand—from vaccines and mAbs to bispecifics and ADCs—the genetic stability of CHO cell lines remains essential for ensuring product quality, safety, and regulatory compliance. Modern sequencing technologies now offer a clearer, more efficient way to evaluate stability than traditional methods that rely on multiple assays and subjective interpretation. Next-generation sequencing provides base-level insight across the entire genome, enabling early detection of drift, structural variants, and other changes that could affect production. When combined with the multi-attribute method (MAM), these tools offer a unified view of both genetic and functional attributes, reducing complexity while increasing confidence in results. An end-to-end platform like Genedata Selector further streamlines NGS-MAM workflows by automating analysis, supporting validation, and maintaining data traceability.

Access the full article to explore how these innovations are shaping the future of CHO cell line development.