From Capture To Final Polishing: Chromatography Consultation Tools For Process Intensification

Process intensification (PI) is reshaping downstream bioprocessing as manufacturers seek to keep pace with upstream productivity gains. Yet, the shift from traditional batch-based systems to intensified workflows is rarely straightforward, especially for facilities with legacy infrastructure. With a wide array of strategies available, from rapid cycling chromatography (RCC) to multi-column chromatography (MCC), selecting the right approach early is essential to maximize efficiency, scalability, and return on investment. Chromatography, often the most costly step in downstream processing, is a natural starting point for PI. Choosing the right media—resins or membranes—requires careful consideration of production constraints, output goals, and facility fit. Modeling tools and expert guidance play a critical role in aligning technology choices with business objectives.

For teams navigating this transition, understanding the trade-offs of each method is key to unlocking the full potential of intensified purification.