Fixing The Fixed: Unlocking Efficiency In Large-Scale Microbial Manufacturing

Many believe that once a bioprocess reaches commercial scale, it's set in stone due to regulatory constraints. However, commercial biomanufacturing is actually quite dynamic.

Explore real-world examples from Lonza’s advanced large-scale microbial facility to show how modern CMC (Chemistry, Manufacturing, and Controls) is continuously evolving. Discover how Lonza achieves ongoing improvements in commercial bioproduction by:

• Optimizing yields through data analysis.
• Refining process flows.
• Systematically analyzing deviations to uncover and fix hidden inefficiencies.

These methods lead to significant gains in reliability, quality, and plant performance. We also highlight how expert teams and the right tools help build resilience and prevent small issues from escalating into costly problems.

Key Takeaways:

• Strategies for maintaining agility and continuous improvement in large-scale commercial manufacturing.
• A comprehensive approach to operational excellence that boosts efficiency and quality.
• Case studies demonstrating Six Sigma tools, process modeling, and deviation management in action.