Filtration Hardware

Cytiva provides a wide range of customized solutions for your filtration needs. UniFlux systems can be customized to operate with hollow-fiber cartridges or  cassettes/hollow fibers. In addition, integrated tanks can be customized (with valves, sensors, mixers, cooling jackets, hoses) to fit particular filtration needs. The flexible UNICORN control system can also be customized to match any desired hardware modifications.

 ÄKTAcrossflow & UNICORN Control Software

Membrane separations are normally used to concentrate and wash feed prior to chromatography. ÄKTAcrossflow is a fully-automated system for cross flow filtration (ultrafiltration/diafiltration and cell separation) during process development and optimization. The benchtop system is compact and has a sanitary design with changeable wetted parts. It can be installed in a laboratory, which reduces facility and infrastructure expenditure.

UNICORN control software means one common control platform and user-interface for all scales of operation in filtration and chromatography. Scouting gives automatic support to process development and optimization. Method wizards and pre-programmed cleaning methods provide a high degree of efficiency. UNICORN is compatible with all applicable regulations, including 21 CFR Part 11.

The system is for use with flat sheet cassettes and hollow fibers. A wide range of cross flow devices include MidGee hollow fiber cross flow cartridges and Kvick Start flat sheet cassettes. The cassettes require small working volumes and are well-suited for ultrafiltration and diafiltration process development. The cassettes have a surface are of 50 cm2 and can be combined for a total surface area of 150 cm2.

UniFlux System

The UniFlux series is a line of cross flow filtration (CFF) systems that utilizes UNICORN software for full automation with data logging capabilites over the entire cross flow process. The systems are intended for pilot through production scale biological separations. These systems are designed to allow linear scalability for both hollow fiber and cassette filters, and for system sizes varying from lab to manufacturing scale. Zero dead-leg drain valves eliminate dead spaces during processing and cleaning. Low working/hold-up volumes ensure higher concentration fact zor capabilities, along with maximal recovered product.

UniFlux systems offer:

• Flexible operation with either hollow fiber or cross flow cassettes
• A broad range of applications covering both ultrafiltration and microfiltration
• Single, familiar UNICORN interface for both chromatography and filtration
• Reduced need for manual controls
• Extensive real time data logging and reporting function

Typical applications

• Monoclonal antibody clarification/concentration
• Recombinant protein concentration
• Vaccine concentration/purification
• Plasma purification/concentration
• Cell harvesting/clarification

GrandStand Pilot / Process Systems

The GrandStand pilot/process system is a versatile, cartmounted system intended for pilot through production scale biological separations from 50 to 10 000 L. It accommodates ultrafiltration and microfiltration hollow fiber cartridges. The GrandStand system is capable of concentration and/or diafiltration.

The basic GrandStand system consists of a heavy-duty stainless steel frame, positive displacement rotary lobe pump for gentle recirculation of biological solutions, diaphragm type backpressure valve, sanitary inlet and outlet pressure gauges, and a cone bottom clean-inplace (CIP) tank. Modular kits enhance the flexibility of the GrandStand systems to meet the needs of process development and process manufacturing groups without the delivery issues associated with custom systems.

Available modules facilitate customization for:

• Varying process volumes
• Data acquisition
• Flow rate
• Pressure
• Temperature
• Conductivity
• UV
• Permeate flow control
• Steam-in-place (SIP)