Newsletter | September 10, 2025

09.10.25 -- Exploring A Universal AAV Purification Method

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As the final step before products reach patients, fill and finish are critical to drug development. On top of quality standards, diverse manufacturing requirements, and evolving regulatory landscapes, the industry is experiencing added pressure from the growth of low-volume therapeutics and multi-product facilities – all resulting in a rising need for flexible manufacturing. Take control of your final formulation and filling by choosing a supplier who combines flexible single-use technologies, trusted regulatory expertise, and industry-leading support.

FOCUS ON DOWNSTREAM MANUFACTURING

Lilly's Exploring A Universal AAV Purification Method

Serotype-specific resins don't scale gracefully. One team at Eli Lilly and Company is exploring an alternative that skips affinity resins altogether.

 

Unpacking The Importance Of Lipid Nanoparticle Production Platforms

Batch processing platforms for LNPs lack efficiency, appropriate controls, and yield optimization. Continuous manufacturing platforms may address some of those issues.

Development Of Improved Chromatographic Methods

Explore the evolving role of GLP-1 agonists in weight management and diabetes care, and discover the urgent need for advanced chromatography methods to ensure pharmaceutical quality and safety.

Process Intensification: Your Guide To "Doing More With Less"

Examine innovative strategies in process intensification to boost mAb production and hear from industry experts as they share solutions for scaling efficiency and navigating regulatory challenges.

Next-Generation Cell Therapy: Eliminating Thermal Shock In Electroporation

Conventional electroporation methods struggle with damaging heat buildup. Discover how innovative flow technology leverages physics to protect cells and enable large-scale therapeutic production.

CHT Chromatography Media: 5 Essential Facts

CHT provides exceptional removal of impurities when other chromatography resins fall short to provide the same level of purity. Explore the essential facts and benefits of this chromatography technology.

DOWNSTREAM MANUFACTURING SOLUTIONS

UF/DF TFF System For Oligo Purification, Product Concentration - Asahi Kasei Bioprocess

Advancing TFF For Small Scale cGMP Production - Repligen

Be A Gain Changer With 2x Throughput - Cytiva

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Webinar: Streamlining Vaccine Purification: Techniques for Modern Modalities

Advances in vaccine development demand faster, more efficient processes. This Thermo Fisher Scientific webinar explores chromatography purification tools that accelerate downstream development for diverse vaccine modalities, including mRNA, viral vectors, recombinant proteins, and VLPs. Through case studies on HPV, Malaria, and COVID-19, attendees will learn how affinity and ion exchange resins enable high-purity, high-yield purification from lab to large-scale production. Click here to learn more.

FOCUS ON FILL-FINISH

Using Algae To Manufacture Oral Biologics With Lumen Bioscience's Craig Behnke, Ph.D.

Lumen Bioscience is putting the farm in biopharma — literally! In this episode of Better Biopharma, Lumen's EVP of production and development, Craig Behnke, Ph.D., explains the company's chlorophyll-powered approach to bioprocessing using photosynthetic cyanobacteria.

Maximizing Yield And Minimizing Risk In Aseptic Filling

Explore the process of how a new fill line was planned for and implemented, while also considering how best to mitigate contamination risks.

Key Metrics In Antibody Drug Development

Learn about key techniques, such as DSC and Rheology, to evaluate thermal stability and viscosity in antibody drug development. Gain insights to enhance candidate selection, formulation, and delivery.

Factors To Consider While Selecting Stoppers For Lyophilized Vials

Ensure the success and stability of your lyophilized products by choosing the right container-closure system — explore your stopper options, here.

Advancements In Aseptic Connection Technologies

Expand your knowledge on the latest innovation in the sterile connector space including the new 1.5” flow path connector, disconnection solution, and more.

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Webinar: Filtration unfiltered: Technology to meet new bioprocessing challenges

Join Cytiva experts as they reveal how to overcome filtration challenges in today’s evolving biopharma landscape. Discover how process intensification drives efficiency, explore strategies for managing diverse drug modalities, and gain insights into key regulatory considerations—including PUPSIT and PFAS. Don’t miss this opportunity to learn how smarter filtration solutions can boost productivity and support sustainable bioprocessing. Click here to learn more.

FILL-FINISH SOLUTIONS

Bora Pharmaceuticals Capacity Update April 2025: Fill/Finish - Bora Pharmaceuticals

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