Evaluating Contamination Control For Open-Vessel Cultivation In The Multitron Shaker With HEPA Filtration

Contamination is a primary concern in cell cultivation, especially when using open vessels. Traditional incubator shakers often require disruptive manual decontamination, interrupting workflows. The Multitron 4 incubator shaker addresses this by incorporating an internal HEPA filtration system. This system continuously filters air, maintaining a Class 10 (ISO 4) environment within minutes of door closure, effectively minimizing airborne particle risks. This application note presents a study evaluating its performance in supporting contamination-free open-vessel cultivation of E. coli and CHO cells. Results from air exposure, surface monitoring, and cultivation comparisons demonstrate clean, uninterrupted cell growth.

Discover how this technology can reduce downtime and enhance workflow efficiency. Read the full application note to learn more.