Advancing Protein Stability Analysis: Enhanced Structural Characterization Of Thermal Unfolding With Microfluidic Modulation Spectroscopy (MMS)

Protein thermal stability directly impacts the efficacy and shelf-life of therapeutic proteins, making its assessment vital for drug development. While conventional techniques like DSF and DSC offer valuable melting temperature data, they often overlook the intricate structural changes occurring during unfolding. This application note examines Microfluidic Modulation Spectroscopy (MMS) as a technique that accurately determines melting temperatures and also provides unique, detailed spectral signatures of structural rearrangements.

Gain a deeper understanding of protein stability by exploring how MMS reveals mechanistic differences in thermal unfolding. Download the application note below to deepen your understanding of protein thermal unfolding.