Enabling Closed-System Bioprocessing With Single-Use Technologies

By Jay Collins, MBA, CAPM®, Product Manager, Charter Medical

Closed-system fluid management has become an important part of modern bioprocessing and advanced therapy manufacturing, helping teams improve sterility assurance while simplifying complex operations. Custom single-use solutions create sterile, integrated pathways across upstream and downstream workflows, from media and buffer preparation through cell processing, harvest, and final fill. By reducing open connections and supporting more adaptable process designs, these assemblies can lower contamination risk, ease scale-up, and speed workflow implementation. They also help manufacturers respond to changing production needs without compromising product quality or integrity.

Explore how a well-designed custom single-use strategy can connect critical process steps and support a more flexible, efficient path from development to manufacturing.