Elevate Cell Line Development With InstiGRO™, InstiSHAKE™, And InstiTHAW™ Supplements

Since the introduction of protein therapeutics, demand has surged, necessitating enhanced production methods that ensure higher capacity and consistent product quality. However, developing stable cell lines for protein therapeutics remains challenging due to various limitations in cell culture practices. Revival and transfection often expose cells to different environmental conditions, such as temperature shifts, osmolarity changes, or chemical exposure, which can stress the cells. Additionally, isolating single cells for regulatory approval can be intricate and may subject the cells to mechanical stress or other factors impacting their health. Furthermore, expanding clones to shaking culture for scalable manufacturing subjects cells to shear forces, affecting their health and productivity.

Advanced Instruments offers a suite of animal component free (ACF) cell growth supplements specifically designed for Chinese Hamster Ovary (CHO) cells. The InstiTHAW, InstiGRO, and InstiSHAKE cell culture supplements are meticulously formulated to protect, nurture, and support the development of stable cell lines, ensuring exceptional growth and performance. InstiTHAW CHO safeguards cells during cryopreservation and revival, while InstiGRO CHO and InstiGRO CHO PLUS promote early cell growth following single-cell isolation. Further, InstiSHAKE CHO supports the expansion of clones to shaking culture conditions, facilitating scalable production of protein therapeutics. Continue reading to learn more about these solutions revolutionizing cell line development.