Newsletter | June 2, 2025

06.02.25 -- Does Continuous Complexity Outweigh Its Benefit?

SPONSOR

Future-Proof Your Process

Mobius® iFlex Bioreactors for upstream processes are a scalable portfolio of stirred tank bioreactors that leverage single-use bags with enhanced strength, made with our innovative Ultimus® film. Perfusion applications are supported with ease by integrating a perfusion tower, that uses the Cellicon® Filter Assemblies to retain cells in the bioreactor vessel while removing spent media. Future-proof your process with modular flexibility, and request a demo or technical consultation with our experts today!

FOCUS ON UPSTREAM MANUFACTURING

Does Continuous Complexity Outweigh Its Benefit?

In this segment of the Bioprocess Online Live event Process Optimization or Full-Scale Automation, David Bruehlmann, Ph.D. addresses how required tech investment, validation times, and staff training impact the return on continuous investment. We also analyze the results of an audience poll on process intensification adoption and discuss energy and perfusion media consumption in continuous versus batch processing.

Achieving Rapid, High-Titer Expression For Next-Generation Biologics

This advanced cell line development technology overcomes production challenges related to the expression and scalability of complex biologics.

Simpler, Faster, Cheaper Advanced Therapy Manufacturing

Discover how TFDF-based perfusion technology boosts lentiviral vector production by over 10-fold, slashes costs, and accelerates the commercialization of CAR-T and other advanced cell therapies.

What Every Scientist Should Know About Their Orbital Throw

Master orbital throw by understanding its impact on aeration, mixing, and growth. Explore recommendations for various applications and the benefits of adjustable throw incubator shakers.

Support The Culture Of Adherent Vero Cells With A Serum-Free Medium

This study compares a serum-free medium to other commercially available pre-hydrated media to measure its effectiveness in supporting the culture of adherent Vero cells.

High-Titer rAAV Production In Bioreactors Using Producer Cell Lines

Here, we detail the upstream process development and optimization for an AAV8-GFP proof-of-concept (PoC) producer single cell clone (SCC) in both batch and perfusion modes.

Utilizing Fed-Batch Intensification To Increase Titer

Learn how the advanced principles of process intensification can be applied to process and equipment design, increasing facility throughput, and ultimately offering a wide range of benefits to customers.

SPONSOR

Webinar: CAR-T Innovation: Balancing Allogeneic & Autologous Cell Therapy

Join us for an insightful webinar addressing critical CAR-T manufacturer pain points and explore strategies to achieve balanced development of allogeneic (off-the-shelf) and autologous (patient-specific) treatments by 2030. Hear how utilizing technology, adaptive regulatory pathways, supply chain and logistics networks, clinical integration, research, and collaboration can improve patient outcomes and advance cell therapy.

UPSTREAM MANUFACTURING SOLUTIONS

Nuvia wPrime 2A Media - Bio-Rad Laboratories, Inc.

Innovations In Transfection And Electroporation - Lonza

Connect With Bioprocess Online: