Discovery And Characterization Of Epitope-Diverse Mismatch Repair (MMR) Protein Antibodies

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by an inherited CAG trinucleotide repeat expansion in the huntingtin gene, with growing evidence implicating DNA mismatch repair (MMR) proteins as key drivers of disease progression. Genome- and transcriptome-wide association studies have identified several MMR pathway components as critical modifiers of HD onset and severity, largely through their role in promoting somatic repeat instability and expansion.

To support deeper investigation of these mechanisms, researchers have developed a comprehensive panel of highly specific, high-affinity monoclonal antibodies targeting FAN1, MLH1, MLH3, MSH2, MSH3, PMS1, and PMS2. These human/rodent cross-reactive antibodies exhibit broad sequence diversity and recognize multiple distinct epitopes per target, enabling robust detection and characterization of MMR proteins.

This next-generation antibody toolkit provides valuable reagents for sensitive immunoassays and visualization studies across biofluids, cells, and tissues. Download the full poster to explore how these novel mAbs can advance understanding of MMR biology and its role in Huntington’s disease progression.