DIANT's Contract Services To Optimize Continuous Nanoparticle Processing

Formulation Development • Process Optimization • Analytical Support • Manufacturing Assistance

DIANT Pharma provides continuous manufacturing systems and technical services for nanoparticle-based formulations. The company’s platform supports both research and manufacturing teams working on lipid nanoparticles (LNPs), liposomes, polymeric micelles, nucleic acid–lipid complexes, and other colloidal systems.

DIANT combines continuous processing with process analytical technology (PAT) integration to enable reproducible formulation, process optimization, and scale-up under controlled and data-driven conditions.

Formulation and Product Development

Nanoparticle formulations require precise control of size distribution, polydispersity, and encapsulation efficiency. DIANT systems enable the development of formulations with repeatable particle characteristics by controlling flow rates, temperature, and mixing conditions within a continuous system.

These capabilities allow researchers to identify the relationship between formulation parameters and material attributes, supporting rational optimization of lipid or polymeric carriers for specific active ingredients or delivery goals.

Outsourced Research & Development

DIANT Pharma offers comprehensive contract research services for organizations seeking to evaluate, develop, and optimize a wide range of nanoparticle formulations. Project scopes can include feasibility assessments, method development, process optimization, pilot-scale production, and scale-up to commercial manufacturing platforms.

Leveraging deep expertise and an extensive knowledge base, the DIANT team eliminates the inefficiencies of trial-and-error experimentation by applying a structured, data-driven formulation strategy. This proven approach minimizes risk, reduces development costs, and significantly accelerates the path from concept to scalable, validated processes.

Flexible Process Analytical Technology Integration

DIANT systems are designed for compatibility with a variety of PAT tools, enabling real-time process monitoring and control. Integrated sensors can track flow, temperature, and particle formation parameters, while optional inline or at-line analytical modules allow continuous assessment of critical quality attributes.

This approach helps establish process understanding, define control strategies, and maintain consistent quality across development and manufacturing stages.

Analytical Method Development and Particle Characterization

DIANT supports analytical method development for nanoparticle systems, including measurement of size, polydispersity, zeta potential, encapsulation efficiency, and stability. These methods provide the data needed to characterize formulations and to understand how process variables affect performance.

Analytical services are aligned with experimental design and technology transfer goals, facilitating integration into existing laboratory or quality systems.

Feasibility Studies

A feasibility study is often the first step in evaluating DIANT’s technology. These studies are designed to establish an initial understanding of how a given formulation behaves under continuous conditions.

Each project includes:

• Evaluation of material and process compatibility
• Definition of key process parameters
• Generation of data on nanoparticle attributes
• Short turnaround times and a defined number of experimental runs

The final report summarizes results, provides recommendations for next steps, and outlines potential pathways for optimization and scaling.

System Customization

DIANT systems can be configured to meet project- or facility-specific requirements. Available options include different throughput capacities, modular hardware designs, automation features, and data collection capabilities. The goal is to align system functionality with users’ research or production needs without major infrastructure changes.

Support During Research and Development

DIANT provides technical support during all stages of nanoparticle R&D. The team includes scientists and engineers experienced in nanoparticle formulation, continuous mixing, and process design. DIANT’s technology is also part of ongoing FDA research initiatives aimed at advancing understanding of continuous manufacturing in the biopharmaceutical field.

This experience allows the team to assist customers in planning experiments, interpreting results, and implementing continuous processing strategies suited to their materials and objectives.

Support for Nanoparticle Manufacturing

For teams moving toward commercial production, DIANT provides continued process and technical assistance. Continuous processing offers several operational advantages over conventional batch approaches, including consistent performance, reduced variability, and simplified scale-up.

Clients may also receive support in developing documentation for process transfer, regulatory submissions, or long-term production planning.

Expert Services: Proof, Optimization, Exploration, and Scaling

DIANT’s service offerings are structured to help clients build and refine their understanding of nanoparticle manufacturing.

Services include:

• Feasibility Evaluation – Determine material compatibility and key process parameters
• Formulation Optimization – Adjust variables to achieve target attributes
• Process Development – Establish process control and reproducibility
• PAT and Data Analytics – Monitor and model process–material interactions

Reports include results from designed experiments, parameter optimization, and statistical analyses. These data sets provide the foundation for defining design spaces and control strategies within regulatory frameworks.

DIANT provides tools and services that connect nanoparticle formulation research with scalable continuous manufacturing. Its systems are adaptable to a range of nanoparticle types and compatible with real-time analytics, offering a framework for systematic process development.

By combining technical expertise, flexible instrumentation, and collaborative service models, DIANT supports both early-stage research and transition to production environments.