Newsletter | November 10, 2025

11.10.25 -- Developing Antibodies To Block Neuroinflammation With MindImmune's Stevin Zorn, Ph.D.

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Webinar: Unlock Productivity in mAb Production: Upstream and Downstream Intensification

Discover how Thermo Fisher Scientific is transforming monoclonal antibody (mAb) production through next-generation process intensification technologies. This webinar highlights innovative upstream and downstream strategies—from high-density cell banking and optimized CHO-K1 media to single-use systems and in-line dilution technologies—designed to streamline workflows, reduce costs, and significantly enhance efficiency across every stage of modern mAb manufacturing. Click here to learn more.

FOCUS ON UPSTREAM MANUFACTURING

Developing Antibodies To Block Neuroinflammation With MindImmune's Stevin Zorn, Ph.D.

In this episode of "Better Biopharma," host Tyler Menichiello is joined by MindImmune's president and CEO, Stevin Zorn, Ph.D. They discuss the development of the company's lead candidate, MITI-101, a monoclonal antibody designed to prevent peripheral immune cells from entering the brain and driving neuroinflammation linked to Alzheimer's disease.

It's Never Too Late To Intensify: Upstream Process Intensification

Explore how early upstream intensification, flexible facility design, and smart technology choices can reduce costs, improve scalability, and support sustainability in low-volume protein therapy production.

Advanced Approaches For Developing And Optimizing Perfusion Platforms

Discover how to effectively use small-scale perfusion-mimic systems to identify optimal cell culture media and significantly increase volumetric productivity for large-scale biomanufacturing.

Single Positive T Cell Differentiation From HiPSC With A Feeder-Free System

Learn about a feeder-free method to differentiate CD8+ single positive T cells from human induced pluripotent stem cells, which offers promising advancements for scalable and efficient cell therapies.

Cell Culture Media Change Protocol

Keep your cells thriving. Learn the essential cell culture media change protocol, including frequency, steps, and tips for optimal cell growth. Discover best practices and avoid common pitfalls.

Exploring Perfusion Technology For Manufacturing Process Intensification

Perfusion cell culture technology supports high cell densities and product yields for viral vaccine manufacturing, offering a reliable way to produce high-quality cells at a commercial scale.

Non-Viral Gene Modification For Ex-vivo Cell Therapy

Understand the advantages of non-viral transfection technologies for CRISPR- or transposon-based genetic modification cell and gene therapy.

Use Of 60 Micron Plastic (PE) Retention Filter For Perfusion Media Exchange

Explore guidance on the materials and methods recommended for assembling a perfusion system using a 60 Micron Plastic (PE) Retention Filter with a Vertical-Wheel Bioreactor.

Next Generation Sequencing For Adventitious Agent Detection In Cell Banks

NGS-based methods for agnostic broad range detection are suitable options to augment or replace current virus testing methodology. Explore a NGS AAT method for cell line characterization and more.

Improving Post-Electroporation Proliferation Rates And Cell Viability

Non-viral gene editing is a powerful method for cell therapy. Learn how to address key challenges like cell viability and thermal damage with an innovative approach designed to improve performance.

UPSTREAM MANUFACTURING SOLUTIONS

Discover Our Collaborative Customer-Focused Approach - INFORS HT

Simplify Assembly & Save Time: Pharma+ Tubing Retainer - Nordson MEDICAL

A Platform For Continuous Glucose And Lactate Control - Repligen – PAT

cGMP CliniControl Products - RoosterBio

Choosing A Cell Expansion Platform - Terumo BCT

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Take a brief tour of Nanoform's advanced nanoformulation, nanoanalytical, and best-in-class capabilities. This video highlights Nanoform’s advanced characterization tools, state-of-the-art formulation technologies, and expert-driven solutions designed to tackle bioavailability challenges. Watch the video now.

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