Designing Quality Into Chromatography Resins To Minimize Variability

By Michael Schulte and Bertram Cezanne

Chromatography resins and adsorptive membranes occupy a central role in the downstream purification of biologics and as such, the raw materials and processes used to manufacture these materials directly impact their performance. Assurance of quality and lot-to-lot consistency begins at the earliest stages of the research and process development phases, when new resins and membranes are being conceptualized and designed to meet the evolving needs of our customers. In this article, we speak with Dr. Michael Schulte (Head of Purification R&D) and Dr. Bertram Cezanne (Head of Chromatography Process Development), about the strategies and close collaboration employed by MilliporeSigma to design quality into resins and membranes and to help customers minimize variability in their purification process.