Demonstrating Millipore Express® SHR Mycoplasma Clearance

For biomanufacturers looking for a higher level of microbial risk reduction than sterilizing-grade filters, our Millipore Express® SHR filters are an attractive option. These filters contain a 0.1 μm polyethersulfone (PES) sterilizing membrane and are designed to efficiently remove mycoplasma contaminants from cell culture media.

Retention studies were performed with Millipore Express® SHR filters and Acholeplasma laidlawii to assess the filter's retention performance over extended filtration times. Results confirmed that both pilot and production-scale filters provide the expected level of mycoplasma retention under long duration, constant flow processing conditions.