Decoding Biologic Performance: Combining SPR And Cell-Based Assays To Drive Development Decisions

Surface-plasmon resonance (SPR) measures physical binding, confirming that a drug candidate interacts with its target. However, binding affinity alone reveals little about downstream cellular mechanisms or true biological impact. Regulatory filings, including Biologics License Applications (BLAs), demand proof of both structural interaction and functional potency.

Integrating SPR analysis alongside functional cell-based assays eliminates isolated analytical data points, building a complete profile of therapeutic activity. Aligning biophysical kinetic parameters directly with cell-based functional readouts enables development teams to construct defensible potency packages supported by clear mechanism-of-action data. Cross-functional analytical workflows resolve property discrepancies earlier, optimize assay design, and prevent costly delays during filing preparation.

Discover how co-located analytical teams translate binding kinetics into actionable biological insights. Watch the full session on demand to strengthen your biologic characterization strategy.