Contrasting Dynamic Binding Capacity Across Affinity Resins

Protein A affinity resins are widely used in therapeutic drug purification, but their cost can be significant. High-capacity protein A resins are preferred as they bind more efficiently to the target molecule, thus reducing costs. This study compares the Dynamic Binding Capacity (DBC) of two Purolite protein A resins and two competitor products in the purification of three types of antibody-related molecules. The study found that Praesto Jetted A50 showed consistent performance across traditional and complex molecules, with a DBC comparable to competitor resins. Praesto Jetted A50 HipH showed the best DBC for the bispecific antibody, and reduced aggregation due to milder pH elution. View the study results that concluded Purolite resins perform comparably across different molecular structures.