Connection Technologies Enable Modular Single-Use Systems For Bioprocessing

By Todd Andrews, Global Director Application & Business Development, Biopharma, CPC

Single-use systems (SUS) are increasingly prevalent in biotechnology processes. Appearing in approximately 85% of all precommercial biomanufacturing, these systems reduce downtime and cross-contamination risks. The biopharmaceutical industry is shifting towards modular SUS, subassemblies that include components like bags, filters, tubing manifolds, and sensors. Modular strategies offer adaptability, SKU rationalization, supply chain protection, and simplified manufacturing integration. Aseptic connectors, such as the AseptiQuik G connector, are crucial in linking sterile fluid streams in these systems. However, modularity presents challenges with its customized designs, making system replication difficult and potentially increasing costs and production timelines. Despite these challenges, connectors enable modularity, allowing product flow from process start to finish. CPC connectors play a critical role in enhancing modular system design flexibility, efficiency, and supply chain assurance. These systems are particularly vital in gene therapies and other biologics requiring closed aseptic processing. The standardization of sterile connectors to all subassemblies within biomanufacturers' networks is a crucial step in adopting modular design.