Conductivity Testing Of Mixing Systems

The speed with which homogeneity is reached within solutions is a critical performance attribute of single-use mixing systems. These systems are commonly used in biopharmaceutical and pharmaceutical media and buffer preparation processes, often involving the hydration of a powder. Recirculation mixing performed using a peristaltic pump can provide a simple and cost effective alternative to more elaborate mixing systems such as those which incorporate a magnetically driven impeller.

This technical bulletin highlights the results of conductivity testing to characterize recirculation mixing performance of single-use systems deployed in Meissner’s QuaDrum^® rigid outer containers (ROCs). All three standard QuaDrum^® ROCs, with nominally rated volumes of 50 L, 100 L and 200 L, were evaluated with corresponding single-use systems. The scope of this testing included varying flow rates and mixing directions while using NaCl as the mixing solute.