Concentrated Fed-Batch Technology

This is an exciting platform technology for cell cultivation. It is a highly versatile process which permits great increases in cell and product concentrations as compared to Fed Batch processing. Fed Batch is widespread in biopharmamaceutical operations: it’s an established platform and relatively repeatable. However, challenges in the industry (such as competitive products for the same indication or desired cost of goods reductions) are forcing many to explore new options. Concentrated Fed-Batch is one such option now gaining ground within the industry with several companies scaling up the process.

The CFB process uses the ATF™ System which simultaneously nourishes the culture and concentrates the product within the bioreactor. Protein product titers of 17g/L in CHO and even higher in other cell lines have been reported. Further improvements in titer are expected as process optimization continues.