Compound Profiling And Toxicity

The Challenge: Understanding a compound’s on and off target activities with associated toxicities and indications Utilizing a systems approach to drug discovery has generated a multitude of high affinity compounds for various classes of molecular targets with different degrees of disease state validation. As these compounds are progressed to the clinic, they pass through a number of defined assays to determine compound efficacy as well as possible toxicities. Although these assays give substantial information on certain toxicities and mechanism of action, toxic effects as well as mechanistic understanding can be found further downstream in the pre-clinical to clinical stage.

It is very useful to have new tools for determining a compound’s propensity for various toxicities earlier on in the process as well as tools for understanding a compound’s on/off target effects as they relate to disease states.