Newsletter | September 30, 2024

09.30.24 -- Complex Protein Development: Assay Early, Assay Often

NEW PODCAST EPISODE

An AI Awakening With Profluent Bio's Hilary Eaton, Ph.D.

Hilary Eaton, Ph.D. was a self-described AI skeptic, particularly regarding using the tool in drug discovery. Then, a series of professional and deeply personal life events and medical discoveries put her in a position to confront that skepticism head-on. On Business of Biotech, the Chief Business Officer at ProFluent Bio shares her story and makes a pragmatic case for the transformative value of AI to biotech builders. Listen now!

FOCUS ON UPSTREAM MANUFACTURING

Complex Protein Development: Assay Early, Assay Often

Experts from FyoniBio, SOTIO, and Vera Therapeutics weigh in with first-hand experience on how process decisions made very early on can influence – beneficially or detrimentally – the efficiency of upstream and even downstream operations in developing novel protein therapeutics.

MSCs “Versus” Or MSCs “Via” T Cells For Cell & Gene Therapy?

We explore how T cells and MSCs don’t have to compete for program time and resources—but can instead work together quite nicely!

Strategies For CMC Development And Optimization In The Production Of Multi-Specific Immuno-Cytokines And Fusion Enzymes

Discover how implementing a strategic approach to optimize the platform can establish a solid foundation for the efficient, reliable, and successful manufacturing of biopharmaceutical products.

Achieve Scalable And High Recovery In rAAV Harvest Process

Explore research on a biodegradable cell lysis solution paired with a quality endonuclease, offering improved particle protection during agitation, reduced foaming and viscosity, and room-temperature storage and shipping.

Mammalian Bioreactors: A Characterization Data Report

Review experiments that characterize the basic operating conditions of mammalian cultures in single-use bioreactors and parameters to be used when transferring cultures to/from other bioreactor systems.

Democratizing Organ-On-A-Chip Technology

Learn about drug development challenges, the evolution of in vitro cell culture towards greater human relevance, a complete solution for creating human-relevant and translatable models, and more.

Overcoming Cell Line Development Challenges With Early-Stage Processes

The biopharmaceutical industry is trending toward building process characterization systems and processes early in a project’s life cycle, enabling success for later-stage development.

Scale-Up Of Ex Vivo Erthroblast Expansion For The Production Of RBCs

This study demonstrates the first steps towards the scaling up of erythroblast expansion in a GMP-compatible bioreactor setup.

DPM Manufacturing: From Development To Large-Scale cGMP Production

This study showcases the success of a two-phase scale-up strategy for the production of dry powder medium (DPM).

Osmolality Analysis In Bioprocessing: From Theory To Practice

Gain deeper insight into the significant impact of osmolality in bioprocessing and its correlation with immunoglobulin G (IgG) production.

How To Maximize Cell Line Productivity And Efficiency

Explore some of the key considerations in cell line development, how advances in technology are improving the efficiency and productivity of cell lines, and the future of cell line development.

History Of The Multitron Incubator Shaker

Learn more about the history of an incubator shaker developed in 1930 and the journey it has taken into the modern era.

UPSTREAM MANUFACTURING SOLUTIONS

Explore The Emulate Organ-Chip Portfolio - Emulate

Support Growth With Material For Cell Culture - Eppendorf SE

A Single-Use, Automated Filtration System For Robust Process Control - Cytiva

RevIT AAV Enhancer – 1.5 mL (For 1 L Of Cell Culture) - Mirus Bio

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