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| Following its popular inaugural 2024 Bio-Expo Live, Bioprocess Online brings you the next opportunity to advance your drug development agenda. Over just a small portion of your week and from the comfort of your computer, discover the latest solutions in upstream and downstream bioprocessing as well as bioprocess quality, data, and analytics. 15-minute presentations from leading suppliers will give you just the right insight to make your next best move in drug development. Register here. |
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FOCUS ON DOWNSTREAM MANUFACTURING |
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By Sandeep Desai, independent subject matter expert | The two most common hot water for injection (WFI) generation methods are multi-effect distillation (MED) and vapor compression (VC). There are significant differences in terms of operational principles and energy efficiency. | |
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| Considerations For High Productivity Membrane Affinity Chromatography | Application Note | By Eric Van Voorhees, Hasan Hashemisohi, Ph.D., W.L. Gore and Associates, Inc.; and Neha Saxena, Ph.D., Shunsuke Shiina, Ph.D., Rodrigo Gonzalez, Ph.D., AGC Biologics Inc. | Explore results from a study aiming to identify hydrodynamic shear rate, cumulative shear stress, and Reynolds number values likely in high-productivity affinity membrane chromatography. |
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| Exosome Isolation By TFF And Size Exclusion Chromatography | Application Note | By Jon Lundqvist, Cytiva and David Haylock, VivaZome | Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography. |
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| Bulk Filling Of Drug Substance | Accurate Aliquoting | Application Note | By Natasha Kelly, Cytiva | This lengthy, manual process relies on operators to adjust pump controls to achieve accurate filling. This method, spanning multiple shifts, increases process risk through errors that can compromise accuracy. |
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DOWNSTREAM MANUFACTURING SOLUTIONS |
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| Webinar: Bioprocess Optimization – Leveraging Functional DOE with Time-based Insights | While traditional Design of Experiments (DOE) methods help identify critical quality attributes and process parameters, they often focus on single-value outcomes, which narrowed focus overlooks the dynamic, time-dependent nature of bioprocesses. Join Samsung as they explore how functional DOE addresses this gap by leveraging time-based data to predict the evolution of key process parameters and uncover complex interactions, providing deeper insights for optimizing bioprocesses. Learn more. |
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| Stopper Migration In Frozen Prefilled Syringes | White Paper | By Jayasree M. Srinivasan, Ph.D., Simtra BioPharma Solutions | Review a semi-automated method for dynamically assessing plunger migration under controlled variations in temperature and pressure, utilizing computer vision tools. |
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