Comparison Between Experimental Data And Computational Fluid Dynamics In Mixing Applications

By Damien Kervennic and Lénaïg Savary; MilliporeSigma and Sid-Ali Ould Khaqua and Karim Loueslati; EUROCFD

In biomanufacturing processes, mixing is ubiquitous. Examples include buffer and media preparation, stirred tank bioreactor/fermentor operation, virus inactivation, DNA digestion, final formulation and beyond. Mixing trials are sometimes necessary to assess if a technical solution is adapted for a given process step or to optimize process parameters. However, trials may not be feasible due to various reasons:

• Product is unavailable in suitable quantities
• Product is too expensive
• Safety issues (e.g., Antibody Drug Conjugates, allergenic)
• Availability of equipment

Discover how computational fluid dynamics can help in your mixing trials.