Characterizing T Cell Exhaustion And Hypofunctionality In Cancer

Investigate what drives the hypofunctional state of T cells in ICB-nonresponsive cancers through the characterization of CD8+ T cell functionality in different tumor types. Different tumors accomplish immune suppression through different mechanisms, and scientists have identified a broad range of intratumoral T cell functional states that influence ICB efficacy. A group of researchers has outlined how their use of a single-cell secretome platform to study the CD8+ T cell landscape in glioblastoma (GBM). Here we learn from their observations, including the GBM-CD8+ T cells display a tolerized-like state rather than tumor reactivity-induced exhaustion.