Challenges And Opportunities For Improved Chromatography Resins

In this video, Professor Giorgio Carta from the Department of Chemical Engineering at the University of Virginia gives an overview of recent advances in the development of resins for protein purification and in understanding protein-surface interactions that are responsible for separation. A particular concern is the potential for protein unfolding on the chromatographic surface that can result in the undesirable formation of unfolded intermediates and aggregates during separation. He presented that new large-pore resins with small particle size based on a hydrophilic backbone can prevent these phenomena resulting in more effective separation.