Cell Line Development Screening: The First Crucial Step For Yield And Critical Quality Attributes

Efficient production of bispecific antibodies (BsAbs) is hindered by challenges including low yield, incorrect chain assembly, and high aggregate levels. Cell line development plays a pivotal role in addressing these issues. By optimizing expression plasmids through strategies such as signal peptide selection and plasmid design, it is possible to enhance BsAb production significantly. The implementation of advanced screening techniques also enables rapid identification of high-yielding clones with superior product quality. This integrated approach, combining plasmid optimization and robust screening, is essential for developing cell lines capable of producing BsAbs with desired yield and critical quality attributes. Download the full article to learn more about Mycenax’s strategic approaches to cell line development for BsAbs.