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Cell Growth Performance In Single-Use Bags

Cell Growth Performance In Single-Use Bags

Achieving consistent cell growth is critically important to the biotech industry. To optimize the final drug product output the current industry trends are towards higher cell densities and protein titers.

With the uptake of single-use bags in cell culture processes, some manufacturers have reported inconsistent cell growth.

Hammond et al – Amgen identified a degradation product, the bis (2,4-di-tert-butylphenyl) phosphate (bDtBPP), derived from a commonly used antioxidant in polyethylene films. However, such antioxidants are necessary to keep films stable. They protect the polymer from oxidation during film extrusion and during gamma irradiation. Therefore, it is extremely important to optimize and closely control the concentration of these additives to ensure proper cell growth.

Sartorius has addressed the challenge of cell growth performance in single-use bags with our well established Flexboy® bags and new Flexsafe® platform.

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