Cell-Free Expression Of A Vaccine Candidate In Scalable Bioreactors

Shigella spp. are bacterial pathogens, that are a leading cause of moderate to severe diarrhea in young children in low- and middle-income countries. Currently, no licensed vaccine to prevent shigellosis is available. Invasion plasmid antigens (Ipas) are promising vaccine targets. These components of the Shigella type III secretion system are highly conserved and therefore vaccines based on them promise to be effective against multiple Shigella serotypes.

Learn the results of a DNA template mixed with an E. coli extract and the components necessary for energy generation and transcription and incubated.