Preparative SMCC: Sequential Multicolumn Chromatography- BioSC® - Columns

Sequential Multi Column Chromatography (SMCC)- Innovative continuous chromatography for biomolecules (e.g. monoclonal antibodies) separation and purification; especially for capture and intermediate chromatography steps in downstream processing.

For almost any chromatographic process, SMCC will break the "Productivity Paradigm" demonstrating improvements in speed, productivity and stationary phase usage of up to 3-fold as well as a reduction in buffer and wash fluid solutions of up to 4-fold, while maintaining both purity and yield performance. The uniqueness of the BioSC-SMCC technology lies in its management of "fluid-in" and "fluid-out" and the ability to asynchronously and flexibly schedule each of the multiple columns.

Typical Applications
Capture and purification of:

• Proteins, e.g.:
  • Monoclonal antibodies
  • Blood / plasma factors
  • Recombinant proteins
• Peptides
• Polysaccharides
• Oligonucleotides
• Viruses

BioSC Product Line Construction materials:

• 316 L stainless steel, acrylic, glass: borosilicate type I, hastelloy, Teflon® seal (compatible with all organic solvents) or EPDM or PEEK or PTFE,
• ASME-BPE: code of construction,
• full material certification package,
• safety & ergonomic tools,
• sanitary fittings, internal finish better than 0.6 µ m, electropolished.

• Significantly more efficient usage of expensive stationary phase
• Significant reduction in CIP and buffer usage
• Downsizing of downstream processing systems and utilities
• Significantly faster processing
• Reduced labor costs through automated process control and analytical analysis
• Supporting PAT initiatives
• Enabling continuous downstream processing
• Improving yield and purity for Biopharmaceuticals