White Paper

Bench To Bedside: Trends In Regenerative Medicine

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This document delves into the advancements and challenges in regenerative medicine, particularly focusing on stem cell transplantation, organoids, and interspecies chimerism. It discusses how recent progress in stem cell biology and gene editing has enhanced translational research, simplifying cell culture and reducing costs. However, issues like the limited growth potential of hematopoietic stem cells (HSCs) and lack of pure population persist. The document also explores the use of organoids for tissue repair, despite their limitations such as long culture time and lack of organ-specific microarchitecture. Furthermore, it discusses the potential of interspecies chimerism for organ transplantation, despite challenges related to evolutionary distance between species and compatibility issues. The document concludes by highlighting the potential of these advancements to significantly impact regenerative medicine and organ transplantation, and address the scarcity of healthy donor organs.

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