Automated Diafiltration (Washing) of Protein Solutions: BioProcessing System Maintains Safe TFF Conditions

The SciPro Smart BioProcessing System™ automates constant volume diafiltration, i.e. removal of undesirable electrolyte (dissolved salts) from dilute protein solutions. In this procedure, the process solution containing the protein is re-circulated through a tangential flow filtration (TFF) device. The undesirable electrolyte is collected as permeate while the protein is left behind as retentate.