Article: Method For Evaluating Bio-Container Transportation Applications

Single-use components are finding more use in the biopharmaceutical industry. One application increasing in use is transportation of sterile liquids. There are many challenges to consider when shipping a flexible container with sterile liquids. Typical Bio-Containers used in shipping applications are constructed of multiple layers. The fluid-contact layer is typically constructed of low, linear low, or ultralow density polyethylene (LDPE, LLDPE, or ULDPE). A variety of gas-barrier layers can be used in construction of the multilayer film, and one typical is ethylene vinyl alcohol (EVO H). The outer layer provides strength and can be constructed of polyethylenes, nylons, or polyesters.

Although the film construction is complex and engineered specifically to endure the harsh conditions it may encounter, Bio-Containers manufactured using plastic have property challenges, such as low penetration resistance, when compared with stainless steel vessels. These containers must be protected during movement inside a manufacturing plant as well as during plant-to-plant transportation. Protective outer containers may range from a portable rack for either hanging or supporting bags in the lay-flat position (for internal plant movements) to fully enclosed totes to protect Bio-Containers from warehouse, truck, and airplane environments.